Guided Tissue Regeneration With Bioabsorbable Barriers. II. Long-Term Results in Infrabony Defects
- Autores: Peter Eickholz, Diana Krigar, Bernadette Pretzl, Harald Steinbrenner, Christof Dörfer, Ti-Sun Kim
- Localización: Journal of periodontology, ISSN 0022-3492, Vol. 75, Nº. 7, 2004, págs. 957-965
- Idioma: inglés
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Resumen
Background: The aim of this 5-year randomized controlled clinical trial was to evaluate the long-term results after guided tissue regeneration (GTR) therapy of infrabony defects using two bioabsorbable barriers.
Methods: Fifteen pairs of contralateral infrabony defects in 15 patients with moderate to severe periodontitis were treated. Each patient received one polydioxanon (test: T) and one polylactide acetyltributyl citrate (control: C) barrier by random assignment. At baseline, 12, and 60 ± 3 months after surgery clinical parameters and standardized radiographs were obtained. Vertical bone levels (PBL-V) were measured during surgery and 60 ± 3 months later by transgingival bone sounding.
Results: Thirteen patients were available for the 60-month examinations. Twelve and 60 ± 3 months after GTR, statistically significant (P ≤0.001) vertical attachment (CAL-V) gain was found in both groups (T12: 3.5 ± 1.5 mm; T60: 2.2 ± 1.8 mm; C12: 4.0 ± 0.9 mm; C60: 2.4 ± 1.0 mm). However, from 12 to 60 months after therapy both groups experienced significant CAL-V loss (P <0.05): two defects in the test group and three in the control group had CAL-V loss >2 mm compared to the 12-month reexamination. Twelve and 60 ± 3 months after surgery, statistically significant (P <0.05) radiographic bony fill was found in both groups (T12: 1.2 ± 1.3 mm; T60: 1.5 ± 2.2 mm; C12: 0.9 ± 1.4 mm; C60: 1.0 ± 1.6 mm). Further, 60 months after surgery significant (P <0.05) PBL-V gain was found in both groups (test: 1.8 ± 2.3 mm; control: 2.2 ± 1.8 mm). The study failed to show statistically significant differences between test and control regarding CAL-V and PBL-V gain 60 months after surgery.
Conclusion: CAL-V gain achieved after GTR therapy in infrabony defects using both bioabsorbable barriers was stable after 5 years in 21 of 26 defects (81%). J Periodontol 2004;75:957-965.
