Immunohistochemical Study of Cyclosporin-Induced Gingival Overgrowth in Renal Transplant Recipients

• Autores: Ömer Engin Bulut
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 75, Nº. 12, 2004, págs. 1655-1662
• Idioma: inglés
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• Resumen

  • Background: Cyclosporin A (CsA) is an immunosuppressant widely used to treat transplant patients and various systemic diseases with immunological components. Gingival overgrowth (GO) is a common side effect of CsA administration; however, the pathogenesis of drug-induced GO is poorly understood. The aim of this study was to evaluate the expression of Ki-67, activation molecules (CD71, CD98), leukocytes activation antigens (CD45, CD45RA, CD50, CD11a, CD162, CD227, CD231), neurothelin (CD147), and novel endothelial cell antigens (B-F45, SCF87, BD46, B-C44, VJ1/6) in gingival tissue in renal transplant recipients treated with CsA.

    Methods: Tissues from 15 renal transplant patients with significant GO and 10 systemically healthy control subjects with gingivitis were studied. Frozen-section biopsies were stained with monoclonal antibodies specific for the above-mentioned antigens using an indirect immunoperoxidase technique.

    Results: Comparison of the CsA-treated and control groups revealed no significant differences with respect to expression of Ki-67; CD50; activation molecules; neurothelin; or novel endothelial cell antigens B-D46, B-C44, and VJ1/6. However, expression patterns of CD45, CD45RA, CD11a, CD162, CD227, CD231, B-F45, and SCF87 were significantly different in CsA and control groups.

    Conclusion: Leukocyte activation antigens play an important role in CsA-induced gingival overgrowth. J Periodontol 2004;75:1655-1662.