Resumen de NMR Studies of Structure–Reactivity Relationships in Carbonyl Reduction: A Collaborative Advanced Laboratory Experiment
Simona Marincean, Sheila R. Smith, Michael Fritz, Byung Joo Lee, Zeinab Rizk
An upper-division laboratory project has been developed as a collaborative investigation of a reaction routinely taught in organic chemistry courses: the reduction of carbonyl compounds by borohydride reagents. Determination of several trends regarding structure–activity relationship was possible because each student contributed his or her results to an overall data set in a situation similar to a research environment. The students learned to use 1H NMR techniques for in situ kinetic determinations and collaborated with classmates to develop a complete theory for structure–activity effects in the kinetics of this fundamental organic reaction.
