NAIP inflammasomes give the NOD to bacterial ligands

• Autores: Vivien I. Maltez, Edward A. Miao
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 35, Nº. 11, 2014, págs. 503-504
• Idioma: inglés
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• Resumen

  • NLRs are innate immune sensors that monitor the sanctity of the cytosolic compartment. In a recent paper in Molecular Cell, Tenthorey et al. reveal a novel ligand-sensing interface within regions of the oligomerization domain of the NAIPs, rather than within the leucine-rich repeats, as was anticipated.