NMR Spectroscopy Using a Chiral Lanthanide Shift Reagent to Assess the Optical Purity of 1-Phenylethylamine

• Tito Viswanathan ^[1] ; Alan Toland ^[1]
  1. [1] University of Arkansas at Little Rock

     University of Arkansas at Little Rock

     Township of Big Rock, Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 72, Nº 10 (October), 1995, págs. 945-946
• Idioma: inglés
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• Resumen

  • Enantiomeric forms of 1-phenylethylamine cannot be distinguished by 1H or 13C-NMR because the groups attached to the stereocenter are in an enantiopic environment. However, the chemical shifts of the protons in the groups attached to the stereocenter can be differentially altered to appear as distinct peaks in the NMR spectrum. This is accomplished by the use of a commercially available chiral lanthanide shift reagent, Yb(tfC)3. The NMR spectrum after the addition of a chiral shift reagent allows one to assess the optical purity of the sample.