Expression of Sox genes in tooth development
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Katsushige Kawasaki [1] ; Maiko Kawasaki [2] ; Momoko Watanabe [1] ; Erik Idrus [1] ; Takahiro Nagai [1] ; Shelly Oommen [2] ; Takeyasu Maeda [1] ; Nobuko Hagiwara [3] ; Jianwen Que [4] ; Paul T. Sharpe [2] ; Atsushi Ohazama [1]
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[1] Niigata University
Niigata University
Nishi Ku, Japón
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[2] Guy's Hospital
Guy's Hospital
Reino Unido
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[3] UC Davis Children's Hospital
UC Davis Children's Hospital
Estados Unidos
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[4] Columbia University
Columbia University
Estados Unidos
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- Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 59, Nº. 10-12, 2015, págs. 471-478
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.
