Interleukin-6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without Cyclosporine A–Induced Gingival Overgrowth

• Ali ^[1] ; Sema ^[2] ; Veli ^[3] ; Harika ^[4] ; Gül ^[5] ; Gülnur ^[6]
  1. [1] Gürkan
  2. [2] Becerik
  3. [3] Özgen Öztürk
  4. [4] Atmaca
  5. [5] Atilla
  6. [6] Emingil

  Mostrar afiliaciones +
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 86, Nº. 9, 2015, págs. 1069-1077
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Background: Interleukin (IL)-6 family of cytokines, including IL-6, oncostatin M (OSM), leukemia inhibitory factor (LIF), and IL-11, have fibrogenic features. The current study determines gingival crevicular fluid (GCF) levels of fibrosis-related IL-6–type cytokines in cyclosporine A (CsA)–induced gingival overgrowth (GO).

    Methods: Eighty non-smokers were included (40 CsA-medicated renal transplant patients with GO [GO+; n = 20] or without GO [GO−; n = 20], 20 individuals with gingivitis, and 20 healthy participants). Probing depth and plaque, papilla bleeding, and hyperplastic index scores were recorded. GCF samples were obtained from the mesio-buccal aspects of two teeth. GCF IL-6, IL-1β, OSM, LIF, and IL-11 levels were analyzed by enzyme-linked immunosorbent assay.

    Results: The GO+ and GO− groups had higher IL-6 total amounts than the healthy group (P <0.008). IL-1β total amounts in the GO+ group were significantly higher than in both the healthy and GO− groups (P <0.008). OSM total amount was elevated in the GO+ and GO− groups compared with both the gingivitis and healthy groups (P <0.008). All groups had similar LIF and IL-11 total amounts (P >0.008). Moderate positive correlations were detected among IL-6, IL-1β, OSM, and IL-11 total amount in GCF and clinical parameters (P <0.05).

    Conclusions: IL-6 and OSM increases in GCF as a result of CsA usage or an immunosuppressed state irrespective of the severity of inflammation and the presence of GO. The IL-6 family of cytokines might not be directly involved in biologic mechanisms associated with CsA-induced GO. Lack of an association between assessed IL-6 cytokines and CsA-induced GO might indicate distinct effects of these cytokines on fibrotic changes of different tissues.