A Prognostic Clinicopathologic Classification of Pituitary Endocrine Tumors

• Autores: Gérald Raverot, Alexandre Vasiljevic, Emmanuel Jouanneau, Jacqueline Trouillas
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 44, Nº. 1, 2015, págs. 11-18
• Idioma: inglés
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• Resumen

  • Pituitary endocrine tumors are considered as benign. However, clinical and pathological data favor their consideration as more than an endocrinological disease. Using data from a retrospective case-control study of 410 patients, with 8 years of follow-up, the authors have validated a new clinicopathologic classification of pituitary tumors. This classification is based on tumor size, immunohistochemical type, and grade based on the assessment of invasion and proliferation, and it provides a prognostic value for predicting postoperative disease-free outcome or recurrence/progression status. This classification aids the identification of patients presenting with pituitary tumors that have a high risk of recurrence and enable construction of personalized therapies.