Enterovirus replication: go with the (counter)flow

• Autores: Jules Nchoutmboube, Lauren A. Ford Siltz, George A. Belov
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 23, Nº. 4, 2015, págs. 183-184
• Idioma: inglés
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• Resumen

  • All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P–cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.