Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones

• Autores: Sandhya S. Visweswariah, Stephen J. W. Busby
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 23, Nº. 8, 2015, págs. 463-467
• Idioma: inglés
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• Resumen

  • Many bacterial transcription factors do not behave transcription factors;

    nucleoid associated proteins;

    bacterial gene regulationas per the textbook operon model. We draw on whole genome work, as well as reported diversity across different bacteria, to argue that transcription factors may have evolved from nucleoid-associated proteins. This view would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.