Rerouting Resistance: Escaping Restriction Using Alternative Cellular Pathways

• Autores: Ailie Marx, Akram Alian
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 23, Nº. 10, 2015, págs. 595-597
• Idioma: inglés
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• Resumen

  • Pathogens, essentially utilizing host machinery for replication, can adapt to exploit cellular redundancies to substitute favored host–pathogen interactions when blocked, leading to a new type of stubborn resistance. Resa-Infante et al. reveal one such ‘rerouting-resistance’ acquired by the influenza virus when a vital host factor was deleted in mice.