Programming Bacteriophages by Swapping Their Specificity Determinants

• Autores: Moran G. Goren, Ido Yosef, Udi Qimron
• Localización: Trends in microbiology, ISSN 0966-842X, Vol. 23, Nº. 12, 2015, págs. 744-746
• Idioma: inglés
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• Resumen

  • Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages’ host specificity by swapping specificity domains in their host-recognition ligand.