The Nlrp3 inflammasome admits defeat

• Autores: Christina J. Groß, Olaf Groß
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 6, 2015, págs. 323-324
• Idioma: inglés
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• Resumen

  • The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory diseases.