Fcγ-receptor tag team boosts anti-tumor immunity

• Autores: Frederick Arce Vargas, Sergio A. Quezada
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 7, 2015, págs. 388-389
• Idioma: inglés
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• Resumen

  • Anti-tumor monoclonal antibodies eliminate tumor cells through different mechanisms including antibody-mediated cell cytotoxicity and generation of long-term anti-tumor T cell responses. In a recent publication, DiLillo and Ravetch demonstrate how this vaccinal effect is mediated by engagement of Fcγ receptors expressed on antigen-presenting cells.