Early evaluation of targeted therapy effectiveness in non-small cell lung cancer by dynamic contrast-enhanced CT
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P.-G. Qiao [1] ; H.-T. Zhang [1] ; J. Zhou [1] ; M. Li [1] ; J.-L. Ma [1] ; N. Tian [1] ; X.-D. Xing [1] ; G.-J. Li [1]
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[1] Academy of Military Medical Sciences
Academy of Military Medical Sciences
China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 1, 2016, págs. 47-57
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Purpose To study the feasibility and clinical value of dynamic contrast-enhanced (DCE) computed tomography (CT) for early evaluation of targeted therapy efficacy in non-small cell lung cancer (NSCLC).
Methods We measured tumor diameter, peak height (PH), time to peak (TP), tumor mass–aortic peak height ratio (M/A), and blood perfusion (BP) in 20 patients with advanced NSCLC using DCE-CT before and 7 days after treatment. Therapy efficacy was assessed with conventional CT 4–6 weeks post-treatment.
Results Patients were grouped into those with partial response (PR), stable disease (SD), and progressive disease (PD) according to the therapy efficacy assessment at 4–6 weeks post-treatment. The PR group primary tumor diameter (P = 0.0007) and BP (P = 0.0225) were reduced at 7 days post-treatment; the SD group DCE-CT value changes were not significant. The PD group M/A (P = 0.0443) and BP (P = 0.0268) were increased 7 days post-treatment. The BP decrease group had significantly longer progression-free survival than the BP increase group (median, 54 vs. 6 weeks).
Conclusion DCE-CT can evaluate targeted therapy efficacy at 7 days post-treatment. Decreased primary tumor diameter and BP indicate tumor sensitivity to therapy; increased BP with unchanged tumor diameter suggests the tumor is not sensitive to therapy. Reduced BP suggests treatment effectiveness.
