Resumen de Carolina M. M. Santana
Ronaldo Barcellos de Santana, Makoto Hirata
Purpose: Bone formation and healing are diminished in experimental type 1 diabetes. The present study investigated whether controlled local release of recombinant human bone morphogenetic protein 2 (rhBMP-2) stimulates bone defect healing in diabetes as a consequence of its anabolic effects on bone. Materials and Methods: Bilateral experimental circular bone defects were created in the temporal bones of 64 BALB/cByJ mice. Defects were treated with acellular collagen sponge plus 0.4 or 1.8 μg of rhBMP-2 per defect, and untreated defects served as controls. The healing of the defects over a 14-day period in diabetic and nondiabetic mice was analyzed histomorphometrically. Results: Diabetes inhibited bone formation in both untreated and BMP-treated bone defects. Controlled local release of rhBMP-2 significantly stimulated bone formation in diabetic animals, bringing it nearly to normal levels, and enhanced bone regeneration in normal animals. Conclusion: Recombinant human BMP-2 may be beneficial in treating deficient intramembranous bone formation in diabetes.
