Experience with Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest

• Levin, Ricardo ^[1] ; Degrange, Marcela ^[2] ; Kennedy, Jason ^[1] ; Porcile, Rafael ; Botbol, Alejandro ^[2] ; Blanco, Norberto ^[2] ; Byrne, John ^[1]
  1. [1] Vanderbilt University Medical Center

     Vanderbilt University Medical Center

     Estados Unidos

     
  2. [2] Universidad Abierta Interamericana

     Universidad Abierta Interamericana

     Argentina

     
• Localización: Revista Argentina de Cardiología (RAC), ISSN-e 1850-3748, ISSN 0034-7000, Vol. 84, Nº. 1, 2016, pág. 1
• Idioma: inglés
• Títulos paralelos:
  • Hipotermia Terapéutica en el Paro Cardiaco Extrahospitalario.
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• Resumen
  • español

    Objetivos: Valorar los resultados del uso de hipotermia terapéutica sobre la sobrevida y el pronostico neurológico de pacientes comatosos resucitados de un paro cardiaco extrahospitalario. Considerar la indicación y hallazgos de la coronariografía y detectar complicaciones asociadas a la hipotermia. Métodos: Fueron incluidos pacientes resucitados de un paro cardiaco extrahospitalario tratados bajo hipotermia terapéutica que consistió en una fase de enfriamiento a 33 grados, un mantenimiento durante 24 horas y recalentamiento a 0.25 grados/hora. Se analizó indicaciones y hallazgos de la cinecoronariografia. Se valoraron complicaciones metabólicas, arrítmicas, infecciosas y hemorrágicas. Un valor de P menor de 0.05 se consideró significativo. Resultados: Doscientos trece pacientes fueron incluidos con una sobrevida hospitalaria de 109 pacientes (51.2%), presentando al egreso 96 pacientes buena recuperación neurológica. Se observó mayor sobrevida en pacientes con ritmos desfibrilables respecto de ritmos no pasibles de desfibrilación, 58.2% versus 37.7%( P=0.007). Ciento cuarenta y siete (69%) pacientes fueron derivados a cinecoronariografia (3.5 horas en promedio) mostrando enfermedad significativa en 121(82.3%), observándose en 69(57%) de ellos oclusión coronaria completa. Ciento siete pacientes fueron angioplastiados, falleciendo 43(40.2%) de ellos durante la internación, frente a 61(58.6%) óbitos entre aquellos no intervenidos o no estudiados (P=0.005). La hipokalemia(87.6%) y la bradicardia sinusal(66.7%) resultaron las complicaciones mas frecuentes. Conclusiones: el empleo de hipotermia terapéutica se asoció con buena sobrevida hospitalaria y pronostico neurológico. La utilización de angioplastia temprana mejoro los resultados. La hipokalemia y la bradicardia sinusal resultaron las complicaciones más frecuentes.

  • English

    Background: Out-of-hospital cardiac arrest (OHCA), one of the leading causes of death in the industrialized world, has a very low survival rate and high incidence of unfavorable neurological outcome among survivors, which have remained stable over the last three decades. The most recent clinical studies have proposed the usefulness of therapeutic hypothermia to reduce mortality and severity of unfavorable neurological outcome in OHCA survivors.Objectives: The aim of this study was to evaluate the mortality and neurological status of comatose patients resuscitated from OHCA treated with therapeutic hypothermia, consider the indications and coronary angiography findings, and detect the complications associated with hypothermia.Methods: Patients resuscitated from OHCA treated with therapeutic hypothermia were included in the study. The procedure consisted of cooling for 24 hours at a target temperature of 33°C followed by rewarming at 0.25°C/hour. The indications and coronary angiography findings were analyzed. The presence of metabolic disorders, arrhythmias, infections and bleeding were also evaluated. A p value <0.05 was considered statistically significant.Results: The cohort consisted of 213 patients. In-hospital survival was 51.2% (n=109) and 46% of these cases (n=96) were discharged with favorable neurological status. Patients with shockable rhythms presented higher survival rates compared with those with non-shockable rhythms (58.2% vs. 37.7%; p=0.007). Coronary angiography was performed in 147 patients (69%) after a mean interval of 3.5 hours: 121 patients (82.3%) presented significant coronary artery disease and 69 patients (58%) had total occlusions. One-hundred and seven patients underwent percutaneous coronary intervention; among these patients 43 (40.2%) died during hospitalization and 61 (58.6%) deaths were reported among those who did not undergo coronary angiography or interventional procedure (p=0.005). The most common complications were hypokalemia (87.6%) and sinus bradycardia (66.7%).Conclusions: The use of therapeutic hypothermia was associated with in-hospital survival >50% and favorable neurological outcome in 46.1% of cases. Mortality was lower in patients undergoing percutaneous coronary intervention. Hypokalemia and sinus bradycardia were the most common complications.