CXCL12 catches T-ALL at the entrance of the bone marrow

• Autores: Tatsuki Sugiyama, Takashi Nagasawa
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 9, 2015, págs. 504-506
• Idioma: inglés
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• Resumen

  • A fraction of patients with T-cell acute lymphoblastic leukemias (T-ALLs) relapse and have a dismal prognosis. Two recent papers in Cancer Cell reveal that endothelial cell-derived CXCL12 is essential for bone marrow involvement and tumor progression in T-ALL patients, suggesting that this chemokine axis presents a potential therapeutic target for the treatment of T-ALL.