Beyond Genomics: Multidimensional Analysis of Cancer Therapy Resistance

• Autores: Mary Philip, Andrea Schietinger
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 11, 2015, págs. 665-667
• Idioma: inglés
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• Resumen

  • Cancer resistance to therapy occurs through a selection process generally thought to be driven by mutations. In a recent study, Hugo et al. use multidimensional analysis of the dynamic genetic, transcriptional, epigenetic, and immune landscape alterations in baseline and MAPK inhibitor-resistant melanoma tumors, demonstrating a role for ‘non-genomic’ drivers in cancer evolution.