Efficient Gene Editing in Primary Human T Cells

• Autores: Yvonne Y. Chen
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 11, 2015, págs. 667-669
• Idioma: inglés
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• Resumen

  • Recent advances in T-cell therapy for cancer, viral infections, and autoimmune diseases highlight the broad therapeutic potential of T-cell engineering. However, site-specific genetic manipulation in primary human T cells remains challenging. Two recent studies describe efficient genome editing in T cells using CRISPR and TALEN approaches.