Asymmetric Cell Division in T Lymphocyte Fate Diversification
- Autores: Janilyn Arsenio, Patrick J. Metz, John T. Chang
- Localización: Trends in immunology, ISSN 1471-4906, Vol. 36, Nº. 11, 2015, págs. 670-683
- Idioma: inglés
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Resumen
Immunological protection against microbial pathogens is dependent on robust generation of functionally diverse T lymphocyte subsets. Upon microbial infection, naïve CD4+ or CD8+ T lymphocytes can give rise to effector- and memory-fated progeny that together mediate a potent immune response. Recent advances in single-cell immunological and genomic profiling technologies have helped elucidate early and late diversification mechanisms that enable the generation of heterogeneity from single T lymphocytes. We discuss these findings here and argue that one such mechanism, asymmetric cell division, creates an early divergence in T lymphocyte fates by giving rise to daughter cells with a propensity towards the terminally differentiated effector or self-renewing memory lineages, with cell-intrinsic and -extrinsic cues from the microenvironment driving the final maturation steps.
