Granulomatous Drug Eruptions

• Autores: Roni P. Dodiuk Gad, Neil H. Shear
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 33, Nº. 3, 2015 (Ejemplar dedicado a: Granulomatous Disorders of Adult Skin), págs. 525-539
• Idioma: inglés
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• Resumen

  • Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis.