Measurement of Postmortem 1,5-anhydroglucitol in Vitreous Humor for Forensic Diagnosis

• Tomoyo Takata ^[2] ; Yukie Yamasaki ^[1] ; Takashi Kitao ^[3] ; Satoru Miyaishi ^[1]
  1. [1] Okayama University

     Okayama University

     Naka-ku, Japón

     
  2. [2] Ehime Prefectural University of Health Sciences Japan
  3. [3] Ehime Prefectural University of Health Sciences Department of Medical Technolog

  Mostrar afiliaciones +
• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 61, Nº. Extra 1, 2016, págs. 150-153
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • In forensic diagnosis, postmortem blood glucose is known to be susceptible to change after death. However, the 1,5-anhy-droglucitol (1,5-AG) concentrations in plasma and cerebrospinal fluid (CSF) reflect the mean blood glucose level for a short period of time. In this study, we compared the postmortem 1,5-AG concentrations in vitreous humor and CSF in 47 subjects to evaluate the utility of this concentration in the vitreous humor for forensic diagnosis. The postmortem 1,5-AG concentrations in vitreous humor (mean+_SD: 20.2+_ 8.7 lg/mL) and CSF (16.8 *-8.7 lg/mL) did not differ significantly and showed a strong correlation (r2= 0.87, p < 0.01). These results suggest that the vitreous humor 1,5-AG concentration provides useful information on the antemortem blood glucose level, in addition to the HbA1c value and the CSF 1,5-AG concentration.