The Genetics of Hidradenitis Suppurativa

• Autores: John R. Ingram
• Localización: Dermatologic clinics, ISSN 0733-8635, Vol. 34, Nº. 1, 2016 (Ejemplar dedicado a: Hidradenitis Suppurativa), págs. 23-28
• Idioma: inglés
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• Resumen

  • A family history of hidradenitis suppurativa (HS) is reported by about one-third of patients, and the pattern of inheritance suggests a single gene disorder inherited as an autosomal dominant trait. Several γ-secretase gene mutations were identified in 6 Han Chinese families with multiple affected family members. Several of the Han Chinese patients had a severe disease phenotype, with involvement of nonflexural skin locations such as the back and chest. These findings have been repeated in other populations, but γ-secretase mutations have been found only in a minority of patients with HS.