Tumor-associated macrophages in cancers

• W. Hu ^[1] ; X. Li ^[1] ; C. Zhang ^[1] ; Y. Yang ^[1] ; J. Jiang ^[1] ; C. Wu ^[1]
  1. [1] The Third Affiliated Hospital of Soochow University, China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 3 (March 2016), 2016, págs. 251-258
• Idioma: inglés
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• Resumen

  • Tumor-associated macrophages (TAMs) are major component of leukocytic infiltrate of tumors and play important roles in progression and regression of tumors. Tumor microenvironment determines the mutual conversion between M1 and M2 macrophages. In many kinds of tumors, M2 type macrophages are of the majority in TAMs and promote tumor progression and metastasis. The dynamic balance and interaction between TAMs and tumor cells have important effects on the occurrence and development of tumor. TAMs in malignant tumors are useful for clinical diagnosis and may provide a novel target for cancer treatment.