Evaluation of mean corpuscular volume difference as a marker for serum hypertonicity during water deprivation in dogs

• Jennifer ^[1] ; Misty ^[2] ; Lisa ^[3] ; Thomas ^[4]
  1. [1] M. Reinhart
  2. [2] R. Yancey
  3. [3] M. Pohlman
  4. [4] Schermerhorn

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• Localización: American Journal of Veterinary Research, ISSN-e 1943-5681, ISSN 0002-9645, Vol. 76, Nº. 2, 2015, págs. 170-173
• Idioma: inglés
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  • Evaluation of mean corpuscular volume difference as a marker for serum hypertonicity during water deprivation in dogs Jennifer M. Reinhart DVM, MS; Misty R. Yancey BS; Lisa M. Pohlman DVM, MS; Thomas Schermerhorn VMD Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506. (Reinhart, Yancey, Schermerhorn); Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506. (Pohlman) Dr. Reinhart's present address is the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.

    Address correspondence to Dr. Reinhart (jreinhart@wisc.edu).

    OBJECTIVE To evaluate mean corpuscular volume difference (dMCV) as a marker for hypertonicity induced by water deprivation in dogs.

    ANIMALS 5 healthy Greyhounds maintained in a research colony.

    PROCEDURES Water was withheld for 24 hours. Blood and urine samples were collected before (time 0) and every 6 hours during water deprivation. Serum and urine osmolality were measured on the basis of freezing point depression, and dMCV was calculated from routine hematologic variables.

    RESULTS Serum and urine osmolality significantly increased and body weight decreased over time in healthy Greyhounds during water deprivation, although most dogs developed only a slight increase in serum osmolality. The dMCV also increased over time, but the value at 24 hours did not differ significantly from the value at time 0. However, a significant correlation was found between serum osmolality and dMCV. A dMCV ≥ 5 fL yielded 100% specificity for predicting hypertonicity when hypertonicity was defined as serum osmolality ≥ 310 mOsM.

    CONCLUSIONS AND CLINICAL RELEVANCE dMCV may be a useful marker for detection of mild hypertonicity in dogs and may have clinical and research applications for use in screening canine populations for hypertonicity.