Prevalence of salivary Epstein-Barr virus in potentially malignant oral disorders and oral squamous cell carcinoma

• Autores: Leticia Bagán Debón, María Dolores Ocete Mochón, Manuel Leopoldo Rodado, Judith Murillo Cortés, José María Díaz Fernández, Rafael Medina-Gonzalez, Concepción Gimeno Cardona, José Vicente Bagán Sebastián
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 21, Nº. 2 (Marzo), 2016
• Idioma: inglés
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• Resumen

  • Background: To analyze the presence of salivary Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma and potentially malignant oral disorders.

    Material and Methods: Three groups were studied: Group 1 (12 oral squamous cell carcinomas (OSCC)), Group 2 (12 potentially malignant oral disorders (PMD)) and Group 3 (47 healthy controls). EBV DNA salivary analysis was performed by PCR.

    Results: The highest percentage of positive salivary EBV DNA corresponded to the OSCC group (58.3%), followed by the PMD group (41.7%) and the controls (40.4%). The differences between groups were not statistically significant, however (p>0.05).

    Conclusions: Salivary EBV DNA was more prevalent in OSCC than in PMD or the controls.