Eosinophilic Esophagitis: Emerging Therapies and Future Perspectives

• Autores: Alex Straumann
• Localización: Gastroenterology clinics of North America, ISSN 0889-8553, Vol. 43, Nº. 2, 2014 (Ejemplar dedicado a: Eosinophilic Esophagitis), págs. 385-394
• Idioma: inglés
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• Resumen

  • Twenty years have passed since eosinophilic esophagitis was first recognized as a new and distinct entity. Current treatment modalities for eosinophilic esophagitis include the “3 Ds”: drugs, allergen avoidance with diet, and esophageal dilation. Drugs entail the limitation that only corticosteroids have a proven efficacy; most other compounds evoke only a minimal effect. Diets must be maintained continuously and they interfere markedly with the quality of life, possibly even involving some risk of malnutrition. A greater understanding of the immunopathogenesis, natural history, and disease spectrum will inevitably lead to improved therapeutic outcomes for this emerging entity.