The Fluid Mechanics of Cancer and Its Therapy

• Petros Koumoutsakos ^[1] ; Igor Pivkin ^[2]
  1. [1] Swiss Federal Institute of Technology in Zurich

     Swiss Federal Institute of Technology in Zurich

     Zürich, Suiza

     
  2. [2] Universita della Svizzera italiana

     Universita della Svizzera italiana

     Lugano, Suiza

     
• Localización: Annual review of fluid mechanics, ISSN 0066-4189, Nº. 45, 2013, págs. 325-355
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Fluid mechanics is involved in the growth, progression, metastasis, and therapy of cancer. Blood vessels transport oxygen and nutrients to cancerous tissues, provide a route for metastasizing cancer cells to distant organs, and deliver drugs to tumors. The irregular and leaky tumor vasculature is responsible for increased interstitial pressure in the tumor microenvironment, whereas multiscale flow-structure interaction processes control tumor growth, metastasis, and nanoparticle-mediated drug delivery. We outline these flow-mediated processes, along with related experimental and computational methods for the diagnosis, predictive modeling, and therapy of cancer.