Granulomatous Colitis of Boxer Dogs

• Autores: Melanie Craven, Kenneth Simpson, Caroline Mansfield
• Localización: Veterinary Clinics of North America: Small Animal Practice: Small Animal Practice, ISSN-e 0195-5616, Vol. 41, Nº. 2, 2011 (Ejemplar dedicado a: Chronic Intestinal Diseases of Dogs and Cats), págs. 433-445
• Idioma: inglés
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• Resumen

  • Granulomatous colitis (GC) is a rare, breed-specific inflammatory bowel disease of young Boxer dogs. GC has been refractory to treatment and associated with high mortality rates, but culture-independent molecular analysis has transformed therapy and prognosis by uncovering a correlation between GC and Escherichia coli invasion within colonic mucosal macrophages. GC-associated invasive E coli are similar to a newly identified E coli pathotype, “adherent and invasive E coli,” that are increasingly associated with Crohn's disease in humans. Successful treatment of GC requires antimicrobials that are effective against E coli and penetrate intracellularly. Enrofloxacin is widely regarded as the antibiotic of choice.