Canine Cytochrome P-450 Pharmacogenetics

• Autores: M. H. Court
• Localización: Veterinary Clinics of North America: Small Animal Practice: Small Animal Practice, ISSN-e 0195-5616, Vol. 43, Nº. 5, 2013 (Ejemplar dedicado a: Clinical Pharmacology and Therapeutics), págs. 1027-1039
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The cytochrome P-450 (CYP) drug metabolizing enzymes are essential for the efficient elimination of many clinically used drugs. These enzymes typically display high interindividual variability in expression and function resulting from enzyme induction, inhibition, and genetic polymorphism thereby predisposing patients to adverse drug reactions or therapeutic failure. There are also substantial species differences in CYP substrate specificity and expression that complicate direct extrapolation of information from humans to veterinary species. This article reviews the available published data regarding the presence and impact of genetic polymorphisms on CYP-dependent drug metabolism in dogs in the context of known human-dog CYP differences