Idiosyncratic Drug Toxicity Affecting the Liver, Skin, and Bone Marrow in Dogs and Cats

• Autores: L. A. Trepanier
• Localización: Veterinary Clinics of North America: Small Animal Practice: Small Animal Practice, ISSN-e 0195-5616, Vol. 43, Nº. 5, 2013 (Ejemplar dedicado a: Clinical Pharmacology and Therapeutics), págs. 1055-1066
• Idioma: inglés
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• Resumen

  • Idiosyncratic drug toxicity reactions are, by definition, uncommon, but can lead to serious or even fatal organ toxicity. The liver, skin, and peripheral blood cells/bone marrow are common targets. Most of these reactions are the result of reactive metabolites, which may cause local cell or organelle damage, or may be amplified by a systemic immune response. Individual risk may depend on differences in drug biotransformation, levels of oxidative stress, or antigen presentation