Glia-derived neurons are required for sex-specific learning in C. elegans

• Autores: Michele Sammut, Steven J. Cook, Ken Q. C. Nguyen, Terry Felton, David H. Hall, Scott W. Emmons, Richard J. Poole, Arantz Barrios
• Localización: Nature: International weekly journal of science, ISSN 0028-0836, Vol. 526, Nº 7573, 2015, págs. 385-390
• Idioma: inglés
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• Resumen

  • Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level—from development, through neural circuit connectivity, to function—the neural basis of a sex-specific learning in the nematode Caenorhabditis elegans. We show that sexual conditioning, a form of associative learning, requires a pair of male-specific interneurons whose progenitors are fully differentiated glia. These neurons are generated during sexual maturation and incorporated into pre-exisiting sex-shared circuits to couple chemotactic responses to reproductive priorities. Our findings reveal a general role for glia as neural progenitors across metazoan taxa and demonstrate that the addition of sex-specific neuron types to brain circuits during sexual maturation is an important mechanism for the generation of sexually dimorphic plasticity in learning.