Resumen de Effect of Exercise Training Modality on C-Reactive Protein in Type 2 Diabetes.

Damon L. Swift, Timothy S. Church, Neil M. Johannsen, Steven N. Blair, Conrad P. Earnest

• Type 2 diabetes is associated with increased risk of cardiovascular disease and elevated C-reactive protein (CRP) levels. Aerobic exercise training has been shown to improve CRP; however, there are limited data evaluating the effect of other exercise training modalities (aerobic, resistance, or combination training) in individuals with type 2 diabetes. Methods: Participants (n = 204) were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. CRP was evaluated at baseline and at follow-up. Results: Baseline CRP was correlated with fat mass, waist circumference, body mass index, and V[spacing dot above]O2peak (P < 0.05). CRP was not reduced after aerobic (0.16 mg[middle dot]L-1, 95% confidence interval (CI) = -1.0 to 1.3 mg[middle dot]L-1), resistance (-0.03 mg[middle dot]L-1, 95% CI = -1.1 to 1.0 mg[middle dot]L-1), or combination (-0.49 mg[middle dot]L-1, 95% CI = -1.5 to 0.6 mg[middle dot]L-1) training compared to control (0.35 mg[middle dot]L-1, 95% CI = -1.0 to 1.7 mg[middle dot]L-1). Changes in fasting glucose (r = 0.20, P = 0.009), glycated hemoglobin (HbA1c) (r = 0.21, P = 0.005), and fat mass (r = 0.19, P = 0.016) were associated with reductions in CRP but not with change in fitness or weight (P > 0.05). There were significant trends observed for CRP among tertiles of change in HbA1c (P = 0.009) and body fat (P = 0.040). Conclusions: Aerobic, resistance, or a combination of both did not reduce CRP levels in individuals with type 2 diabetes. However, exercise-related improvements in HbA1c, fasting glucose, and fat mass were associated with reductions in CRP. (C)2012The American College of Sports Medicine