Hallmarks of pluripotency

• Autores: Alejandro de los Ángeles, Francesco Ferrari, Ruibin Xi, Yuzo Fujiwara, Nissim Benvenisty, HongKui Deng
• Localización: Nature: International weekly journal of science, ISSN 0028-0836, Vol. 525, Nº 7570, 2015, págs. 469-478
• Idioma: inglés
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• Resumen

  • Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.