TLS in Tumors: What Lies Within

• Autores: Catherine Sautès Fridman, Wolf Herman Fridman
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 37, Nº. 1, 2016, págs. 1-2
• Idioma: inglés
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• Resumen

  • The role of tertiary lymphoid structures (TLS) in cancer has recently been illustrated and revisited using mouse models. Joshi et al. describe regulatory T (Treg) cell infiltration and functional heterogeneity of TLS in lung tumors. Finkin et al. report that inflammation-associated TLS serve as niche for tumor progenitor cells, which may lead to recurrence in hepatocellular-carcinoma.