Reprogramming the T Cell Response to Tuberculosis

• Autores: Joshua S. Woodworth, Peter Andersen
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 37, Nº. 2, 2016, págs. 81-83
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Coscolla, Copin et al. recently used comparative genomics of M. tuberculosis (Mtb) strains to show that most human T cell-recognized epitopes are hyperconserved, but bona fide variable epitopes also exist. This identification of two sets of antigens implies opposing evolutionary processes and will have an important impact on tuberculosis (TB) vaccine strategy and design.