Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota

• Autores: Oliver Pabst, Vuk Cerovic, Mathias Hornef
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 37, Nº. 5, 2016, págs. 287-296
• Idioma: inglés
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• Resumen

  • Starting at birth, the intestinal microbiota changes dramatically from a highly individual collection of microorganisms, dominated by comparably few species, to a mature, competitive, and diverse microbial community. Microbial colonization triggers and accompanies the maturation of the mucosal immune system and ultimately results in a mutually beneficial host–microbe interrelation in the healthy host. Here, we discuss the role of secretory immunoglobulin A (SIgA) during the establishment of the infant microbiota and life-long host–microbial homeostasis. We critically review the published literature on how SIgA affects the enteric microbiota and highlight the accessibility of the infant microbiota to therapeutic intervention.