Laboratory Diagnosis of Lyme Disease

• Autores: Adriana R. Marques
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 29, Nº. 2, 2015 (Ejemplar dedicado a: Lyme Disease and Other Infections Transmitted by Ixodes scapularis), págs. 295-307
• Idioma: inglés
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• Resumen

  • The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field.