Comparative Analysis of Calcium-Binding Myeloid-Related Protein-8/14 in Saliva and Serum of Patients With Periodontitis and Healthy Individuals Hady Haririan, Oleh Andrukhov, Eleonore Pablik, Michaela Neuhofer, Andreas Moritz and Xiaohui Rausch-Fan

• Autores: Hady Haririan, Oleh Andrukhov, Eleonore Pablik, Michaela Neuhofer, Andreas Moritz Sánchez, Dr. Xiaohui Rausch-Fan
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 87, Nº. 2, 2016, págs. 184-192
• Idioma: inglés
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• Resumen

  • Background: This study aims to investigate calcium-binding myeloid-related protein (MRP)-8/14 in the saliva and serum of individuals with periodontitis and periodontally healthy individuals for the assessment of its role in the pathogenesis and clinical diagnosis of periodontitis.

    Methods: This cross-sectional study includes 56 patients with periodontitis and 44 periodontally healthy individuals. Saliva and serum were collected for the detection of MRP-8/14 and calcium levels. Periodontopathic bacteria were determined by polymerase chain reaction in saliva. Correlations between salivary and serum MRP-8/14 levels and clinical parameters, bacteria, and calcium were analyzed with Pearson correlation in a multiple regression model. MRP-8/14 levels were documented with receiver operating characteristic (ROC) curves.

    Results: Compared with healthy individuals, MRP-8/14 levels were significantly higher in both the saliva and serum of patients with periodontitis, but calcium was increased only in saliva. A high diagnostic potential of salivary MRP-8/14 was detected for periodontitis (ROC = 0.86). Salivary MRP-8/14 levels correlated significantly with the presence of the periodontopathogen Treponema denticola, as well as with the clinical parameters of periodontitis.

    Conclusion: MRP-8/14 in saliva might be a potential diagnostic parameter for periodontal disease.