Effect of Aspirin Supplementation on Hemodynamics in Older Firefighters.

• Autores: Denise L. Smith, Sushant M. Ranadive, Huimin Yan, Abbi D. Lane, Rebecca Marie Kappus, Peng Sun, Kanokwan Bunsawat, Gavin P. Horn, Robert J. Ploutz-Snyder, Bo Fernhall
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 47, Nº. 12, 2015, págs. 2653-2659
• Idioma: inglés
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• Resumen

  • AB Purpose: Cardiovascular events are the leading cause of line-of-duty fatality for firefighters. Aspirin reduces the risk of cardiovascular events in men and may reduce fatalities in older (>40 yr) firefighters. We hypothesized that both chronic and acute aspirin supplementation would improve vascular function after live firefighting but that chronic supplementation would also improve resting hemodynamics. Methods: Twenty-four firefighters (40-60 yr) were randomly assigned to acute or chronic aspirin supplementation or placebo in a balanced, crossover design. Arterial stiffness, brachial and central blood pressures, as well as forearm vasodilatory capacity and blood flow were measured at rest and immediately after live firefighting. Results: Total hyperemic blood flow (area under the curve (AUC)) was increased (P < 0.001) after firefighting with no effects for aspirin supplementation or acute versus chronic administration (AUC, from 107 +/- 5 to 223 +/- 9 in aspirin condition and from 97 +/- 5 to 216 +/- 7 mL[middle dot]min-1 per 100-mL forearm tissue for placebo; P < 0.05 for main, and P > 0.05 for interaction). Arterial stiffness/central blood pressure increased (P < 0.04) with no effect of aspirin (from 0.0811 +/- 0.001 to 0.0844 +/- 0.003 m[middle dot]s-1[middle dot]mm Hg-1 in aspirin condition versus 0.0802 +/- 0.002 to 0.0858 +/- 0.002 m[middle dot]s-1[middle dot]mm Hg-1 in placebo condition), whereas peripheral and central systolic and pulse pressures decreased after firefighting across conditions (P < 0.05). Conclusions: Live firefighting resulted in increased AUC and pressure-controlled arterial stiffness and decreased blood pressure in older firefighters, but aspirin supplementation did not affect macro- or microvascular responsiveness at rest or after firefighting.