Studying the Elusive Environment in Large Scale

• Autores: Chirag Patel, John P. A. Ioannidis
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 311, Nº. 21, 2014, págs. 2173-2174
• Idioma: inglés
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• Resumen

  • It is possible that more than 50% of complex disease risk is attributed to differences in an individual’s environment.1 Air pollution, smoking, and diet are documented environmental factors affecting health, yet these factors are but a fraction of the “exposome,” the totality of the exposure load occurring throughout a person’s lifetime.1 Investigating one or a handful of exposures at a time has led to a highly fragmented literature of epidemiologic associations. Much of that literature is not reproducible, and selective reporting may be a major reason for the lack of reproducibility. A new model is required to discover environmental exposures associated with disease while mitigating possibilities of selective reporting.