Dr Muzaale and colleagues1 reported the estimated lifetime risk of end-stage renal disease (ESRD) in donors as 0.9% compared with 0.14% in healthy nondonors and 3.26% in unscreened nondonors (general population), an 8-fold higher cumulative incidence of ESRD in donors compared with healthy nondonor controls. These data are important for discussions with prospective donors, especially donors of African American descent who have the highest relative
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