Basic Genetics and Immunology of Candida Infections

• Autores: Xiaowen Wang, Frank L. van de Veerdonk, Mihai G. Netea
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 30, Nº. 1, 2016 (Ejemplar dedicado a: Fungal Infections), págs. 85-102
• Idioma: inglés
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• Resumen

  • Candida infections can cause superficial and invasive disease. Several essential mechanisms underlying the pathogenesis of these infections were known for some time, such as neutropenia predisposing to invasive disease, and CD4 lymphopenia causing increased susceptibility to mucosal candidiasis. However, the development of novel genetic screening techniques has led to several new insights in the genetics and immunology of candida infections. This article highlights novel insights in the pathogenesis of mucocutaneous and invasive candidiasis that have been identified in recent years.