Effect of nutritional recovery on serum concentration of lipoperoxides in children with severe protein-energy malnutrition

• Autores: Edgar Manuel Vásquez Garibay
• Localización: Journal of Negative and No Positive Results: JONNPR, ISSN-e 2529-850X, Vol. 1, Nº. 4, 2016, págs. 149-155
• Idioma: inglés
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  • Summary. Objective. The purpose is to show lipid peroxide’s serum concentration trend during a four-week nutritional recovery period in children with primary and severe protein energy malnutrition (PEM).Methods. In a clinical intervention 12 primarily and severely malnourished children (three to 48 months of age) were included. Dependent variable: Serum lipid peroxide (LPO) concentration (nmol/mL). Independent variables: non lactose starting infant formula (200 kcal/kg/d and proteins 4 g/kg/d). Age, sex, nutritional recovery, weight/age, length/age and weight/length indices calculated and expressed as Z scores were included. For statistical analysis a repeated measure ANOVA model was applied. A non-parametric Mann Whitney U-Test was used to compare groups. Null hypothesis was rejected with a p value £ 0.05.Results. Throughout the study the LPO concentration was higher in subjects with PEM than in the control group (p< 0.001). There was a decrease in the LPO concentration (nmol/mL) between basal vs. two weeks (12.9 vs. 7.3, p = 0.06) and basal vs. four weeks (12.9 vs. 8.16, p = 0.08).Conclusion. LPO concentrations were significantly higher in children with severe PEM at the beginning and end of the four-week nutritional recovery period. This finding was probably associated with increased metabolism of the cellular tissue and/or the high consumption of energy and nutrients compared to a control group. The null hypothesis of basal-end differences in LPO serum concentrations could not be rejected due to the great variability in serum lipoperoxides in these children with severe primary protein-energy malnutrition.Word count: 242