Resumen de An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

Rafał Pawłowski, Eeva Kaisa Rajakylä, Maria K Vartiainen, Richard Treisman

• The transcriptional coactivator MRTF-A/Mal binds G-actin, which sequesters it in the cytoplasm. In this study, Treisman and colleagues identify an unusual bipartite nuclear localisation signal in MRTF-A, and show that importin α/β-mediated import through this NLS is directly inhibited by G-actin binding.