Resumen de Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum
Timothy J Tavender, Jennifer J. Springate, Neil J. Bulleid
Ero1 is thought to be the only oxidase that mediates the re-oxidation of protein disulphide isomerases (PDIs) during oxidative protein folding in the ER. This study reveals that peroxiredoxin IV can also directly oxidize PDI-family members and thus act as a second source of oxidizing equivalents for disulphide-bond formation in the ER.
