Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check

• Nam Ky Tonthat ^[1] ; Stefan T Arold ^[1] ; Brian F Pickering ^[2] ; Michael W Van Dyke ^[2] ; Shoudan Liang ^[1] ; Yue Lu ^[1] ; Tushar K Beuria ^[3] ; William Margolin ^[3] ; Maria A Schumacher ^[1]
  1. [1] University of Texas MD Anderson Cancer Center

     University of Texas MD Anderson Cancer Center

     Estados Unidos

     
  2. [2] Western Carolina University

     Western Carolina University

     Township of Cullowhee, Estados Unidos

     
  3. [3] Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, Houston, TX, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 1, 2010, págs. 154-164
• Idioma: inglés
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  • Nucleoid occlusion (NO) restricts bacterial cell division to prevent chromosome guillotining in the cell midzone when replication or segregation is delayed. Structural work suggests that the NO factor SlmA (synthetic lethal with a defective Min system) interferes with formation of the cytokinetic Z-ring by altering associations between FtsZ protofilaments.