Resumen de Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

Sabine Lagger, Dominique Meunier, Mario Mikula, Reinhard Brunmeir,, Michaela Schlederer, Matthias Artaker, Oliver Pusch, Gerda Egger, Astrid Hagelkruys, Wolfgang Mikulits, Georg Weitzer, E. W. Muellner, Martin Susani, Lukas Kenner, Christian Seiser

• Although histone deacetylases are generally known as pro-tumourigenic factors, loss of HDAC1 is here shown to promote proliferation and inhibit differentiation in a mouse teratoma model, at least partly via regulation of the transcription factor SNAIL1.