A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion

• Alexander Kurze ^[1] ; Katharine A Michie ^[2] ; Sarah E Dixon ^[1] ; Ajay Mishra ^[1] ; Takehiko Itoh ^[3] ; Syma Khalid ^[4] ; Lana Strmecki ^[1] ; Katsuhiko Shirahige ^[5] ; Christian H Haering ^[6] ; Jan Löwe ^[2] ; Kim Nasmyth ^[1]
  1. [1] University of Oxford

     University of Oxford

     Oxford District, Reino Unido

     
  2. [2] MRC Laboratory of Molecular Biology

     MRC Laboratory of Molecular Biology

     Cambridge District, Reino Unido

     
  3. [3] Tokyo Institute of Technology

     Tokyo Institute of Technology

     Japón

     
  4. [4] University of Southampton

     University of Southampton

     GB.ENG.M4.24UJ, Reino Unido

     
  5. [5] University of Tokyo

     University of Tokyo

     Japón

     
  6. [6] European Molecular Biology Laboratory, Heidelberg, Germany

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 30, Nº. 2, 2010, págs. 364-378
• Idioma: inglés
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• Resumen

  • DNA has been suggested to enter ring-shaped cohesin complexes via a structural maintenance of chromosome (SMC) protein dimerization interface. Structure-based analyses now show that a positively charged channel within this hinge region, while being dispensable for SMC dimerization and cohesin loading, is essential for cohesin acetylation and establishment of sister chromatid cohesin during S phase.